from microbiology to advanced chromatography technology


We are focused on the innovation of chemical purification and industrial processes. High-performance chromatography, flow chemistry, process study and design, recombinant DNA technology are common tools in BioC-CheM Solutions activity

We have the expertise to address all your purification needs, from milligrams to hundreds of grams

• Analytical reference standards preparation
• Pure compounds from complex natural matrices
• Industrial chromatographic process development (reverse phase, normal phase, ion exchange, SEC) up to pilot
• Special focus on isolation and identification of impurities

We commercialize and have analytical reference standards for the market
• Teicoplanin
• Ramoplanin
• Lysergic acid
• A40926 
• Dalbavancin
• Thermorubin
• Kirromycin
• GE2270 

We guarantee the better industrial performance of processes 

Laboratory-scale experiments and pilot experiments are conducts to transfer your process to industrial level.
Owen to our technical expertise in downstream processes (DSP) for recovery of sensitive compounds and our foresight of industrial feasibility for the targeted applications, we can guarantee processes efficiencies and economically favourable. 

We prepare custom chemical compounds, from milligram to multigram scale 

• Reference standard
• Final and intermediate products of fine chemical
• Semi-synthetic derivatives
• Selective modifications   

We can help your company to develop tailor-made enzymes and provide assistance for their industrial production and application.

• Deacylations
• Selective oxidations
• Extremophiles derived enzymes performing new chemical transformations or have improved tolerance towards temperature, pH and organic solvents

Our ability to manipulate uncommon microorganisms (purification, mutagenesis and selection, gene directed modifications) allows the rapid introduction of the microorganisms in the industrial processes cycle.From the simple production of microbial biomass for bioremediation or crop field application to the production of the most complex secondary metabolites are common challenges in our activity .
We have developed proprietary strains and bioprocesses for the preparation of microbial products. The most representatives in our pipeline are:

Secondary metabolites
• Dalbavancin. Lantabiotics, Teicoplanin, Ramoplanin.
Thermorubin Anidulafungin
• Glycopeptides
• Ergot alkaloids and derivatives
• Statins
• Mycophenolic acid
• Echinocandins

High-value enzyme
• Transglutaminase
• Peroxidases and laccases
• Proteases for enzyme therapy

Functional Molecules
• Biosurfactants

Cell & Biomass
• Luminescent Microorganisms
• Biomass for in situ bioremediation
• Spores (bacterial and fungal) for agriculture 

Lyophilization is applied in the long-term preservation of:
• Biological samples
• Pharmaceutical products
• Media for cell cultures and fermentation
• Microorganisms
• Proteins and enzymes
• Food products

BioC-CheM Solutions offers freeze-drying services for chemicals, biologicals and for microorganisms. The identification of the critical lyophilization parameters, allows us to set-up the best process for long term storage. We assist our clients in the development in custom lyophilization processes and we deliver lyophilized products in a timely manner.

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By Italbiotec